AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE
ISSN 0036-8075
SCIENCE
4 OCrOBER I99I VOLUME 254 NUMBER 5O28
7 This Week in Science
9 Instrumentation: J. I. BRAUMAN 11 Brain Tumor Incidence at Los Alamos: S. S. HECKER S Peer Review and Patent Rights: B. R. GREENBERG S Volcanoes: How Dangerous?: D. J. Bowxs Correction: S. M. RUBEN, P. J. DILLON, R. SCHRECK, T. HENKEL, C.-H. CHEN, M. MAHER, P. A. BAEUERLE, C. A. ROSEN
19 NASA scrambles to save rocket program; Europeans debate patenting of life; etc.
30 32 33 34 35 36
Doing Chemistry in the Round A Long Look in the Extreme Ultraviolet A Hand on the Bird-And One on the Bush Gamma-Ray Observatory: Bursting with New Results Transgenic Animals May Be Down on the Pharm A First Investment in a Kaon Factory a Some Would KO KAON Instrumentation
43 Echo-Planar Imaging: Magnetic Resonance Imaging in a Fraction of a Second: M. K. STEHLING, R. TURNER, P. MANSFIELD 51 Determination of Macromolecular Structures from Anomalous Diffraction of Synchrotron Radiation: W. A. HENDRICKSON 59 Large-Scale and Automated DNA Sequence Determination: T. HUNKAPILLER, R. J. KAISER, B. F. Koop, L. HOOD
68 Chemical Imaging of Surfaces with the Scanning Electrochemical Microscope: A. J. BARD, F.-R. F. FAN, D. T. PIERCE, P. R. UNWIN, D. 0. WIPF, F. ZHOU 74 Chemical Microsensors: R. C. HUGHES, A. J. RICCO, M. A. BUTLER, S. J. MARTIN aSLI
81 Detection of Somatic DNA Recombination in the Transgenic Mouse Brain: M. MATSUOKA, F. NAGAWA, K. OKAzAmI, L. KINGSBURY, K. YOSHIDA, U. MULLER, D. T. LARUE, J. A. WINER, H. SAKANo *
*
4
SCIENCE (ISSN 0036-8075) is published weeldy on Friday, except the last week In Dember, by the Ameican Association for the Advancement of Science, 1333 H Street, NW, Washington, DC 20005. Second-class postage (publication No. 484460) paid at Washington, DC, and additional mailing offices. Copyright © 1991 by the American Association for the Advancement of Science. The title SCIENCE is a registered trademark of the AAAS. Domestic individual membership and subscription (51 issues): $82 ($47 allocated to subscription). Domestic institutional subscription (51 issues): $150. Foreign postage extra: Mexico, Caribbean (surface mail) $50; Other countries (air assist delivery) $95. First class, airmail, student and emeritus rates on request. Canadian rates with GST available upon request, GST #1254 88122. Change of address: allow 6 weeks, giving old and new addresses and 1 1-digit account number. Postmaster: Send change of address to Science, P.O. Box 2033, Marion, OH 43305-03. Single copy salee: $6.00 per issue prepaid includes surface postage; Guide to Biotechnology Products and Instruments, $20. Bulk rates on request. Authorization to photocopy material for internal or personal use under circumstances not falling within the fair use provisions of the Copyright Act is granted by AAAS to libraries and other users registered with the Copyright Clearance Center (CCC) Transactional Reporting Service, provided that the base fee of $1 per copy plus $0.10 per page is paid directly to CCC, 27 Congress Street, Salem, Massachusetts 01970. The identification code for Science is 0036-8075183 $1 + 1 0. Science is indexed in the Reader's Guide to Periodical Lterature and in several specialized indexes. The American Association for the Advancement of Science was founded in 1848 and incorporated in 1874. Its objectives are to further the work of scientists, to facilitate cooperation among them, to foster scientific freedom and responsibility, to improve the efectiveness of science in the promotion of human welfare, to advance education in science, and to increase public understanding and appreciation of the importance and promise of the methods of science in human progress.
SCIENCE, VOL. 254
Downloaded from http://science.sciencemag.org/ on June 28, 2018
20 A Is for Apple, Alar, and ... Alarmist? a A Bite Out of the Market 23 Free Speech and Clinical Trials Emphasizing the Health in NIH 24 Glenn Uncovers the Great Pizza Scandal 25 Reproductive Toxicity: Regulation Slow to Change 26 East Germany: Science in the Disservice of the State 28 Briefings: Whistleblowing for Fun and Profit a The Hunt for Drugs From Nature a GOES-NEXT to Wait Out Next Round a Creme de la Creme a U.S. Still Balks at Greenhouse Talks a No Quick Fixes for Learning a Water Couldn't Dash This BBQ
COVER A cloud pouring over the western face of the Sentinel Range, Ellsworth Mountains, Antarctica. Fission-track analysis of samples from the Vinson Massif, Antarctica's highest mountain (4897 meters; 8 kilometers south of this photo), indicates that the Ellsworth Mountains were uplifted more than 4 kilometers during the Early Cretaceous (between 141 and 117 million years ago) and that at least 1.8
kilometers of relief has persisted since then. See page 92. [Photo by Ed Stump]
122 Mathematical Analysis of a Model of the Mitotic Clock: C. D. THRON 128 AAAS*92: The AAAS Annual Meeting, 6-11 February, Chicago * Symposia * Featured Speakers * Seminars * Employment Exchange * Call for Poster Papers & Student Research Award Entries * Forms and Instructions
*S-k
133 Plants, Power, and Profit, reviewed by R. J. THOMAS a A Simple Matter of Salt, A. V. MILLARD a The Comparative Method in Evolutionary Biology, D. B. MILES a Recent Books on Instrumentation and Techniques 137 Amplification Complementary DNA m Mass Analyzer m Handheld Homogenizer a CO2 Incubator a Automatic Capillary Electrophoresis a Size-Exclusion HPLC Columns a One-Step Nucleic Acid Isolation * Literature
Board of DIrectors Donald N. Langenberg
Retinng President, Chairman Leon M. Lederman President F. Sherwood Rowland
President-lect
Mary Ellen Avery Francisco J. Ayala Eugene H. Cota-Robles Robert A. Frosch Joseph G. Gavin, Jr. Florence P. Haseltine Jean'ne M. Shreeve Warren M. Washington William T. Golden Treasurer
Richard S. Nicholson
Exectve Officer
4 OCTOBER 1991
Editra
Board Charles J. Amtzen Elizabeth E. Bailey David Baltimore William F. Brinkman E. Margaret Burbidge Pierre-Gilles de Gennes Joseph L. Goldstein Mary L. Good Harry B. Gray John J. Hopfield F. Clark Howell Paul A. Marks Yasutomi Nishizuka Helen M. Ranney Robert M. Solow Edward C. Stone James D. Watson
Board of
Reviewing
Editors John Abelson Frederick W.
Alt
Don L. Anderson Stephen J. Benkovic David E. Bloom Floyd E. Bloom Henry R. Boume James J. Bull Kathryn Calame Charles R. Cantor C. Thomas Caskey Dennis W. Choi Ralph J. Cicerone John M. Coffin Bruce F. Eldridge Paul T. Englund Fredric S. Fay
Douglas T. Fearon Harry A. Fozzard Victor R. Fuchs Theodore H. Geballe Margaret J. Geller Roger 1. M. Glass
Stephen P. Goff Corey S. Goodman Stephen J. Gould
Ira Herskowitz Eric F. Johnson Stephen M. Kosslyn Konrad B. Krauskopf Charles S. Levings Ill Harvey F. Lodish Richard Losick Anthony R. Means Mortimer Mishkin Roger A. Nicoll William H. Orme-Johnson Ill
Stuart L. Pimm Yeshayau Pocker Dennis A. Powers Ralph S. Quatrano Erkki Ruoslahti Thomas W. Schoener Ronald H. Schwartz Terrence J. Sejnowski Thomas A. Steitz Robert T. N. Tjian Emil R. Unanue Geerat J. Vermeij Bert Vogelstein Harold Weintraub Zena Werb George M. Whitesides Owen N. Wite William B. Wood Keith Yamamoto
TABLE OF CONTENTS
5
Downloaded from http://science.sciencemag.org/ on June 28, 2018
87 Energy Transfer Between Two Peptides Bound to One MHC Class II Molecule: R. TAmpE, B. R. CLARK, H. M. MCCONNELL 89 Periodic Hot-Spot Distribution on lo: A. YAMAJI 92 Early Cretaceous Uplift in the Ellsworth Mountains of West Antarctica: P. G. FrrzGERALD AND E. STUMP 94 A Dominant Negative Form of Transcription Activator mTFE3 Created by Differential Splicing: C. RoMAN, L. COHN, K. CALAME 97 A Mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease: J. MURRELL, M. FARLow, B. GHETrI, M. D. BENSON 99 Regulation of Transendothelial Neutrophil Migration by Endogenous Interleukin-8: A. R. HUBER, S. L. KUNKEL, R. F. TODD, III, S. J. WEISS 102 Suppression of the Immune Response by a Soluble Complement Receptor of B Lymphocytes: T. HEBELL, J. M. AHEARN, D. T. FEARON of Divergent HIV-1 Isolates by Conformation-Dependent Human Neutralization 105 Antibodies to Gp120: K. S. STEIMER, C. J. SCANDELLA, P. V. SKILES, N. L. HAIGWOOD A Bacterial System for Investigating Transport Effects of Cystic 109 Fibrosis-Associated Mutations: A. L. GIBSON, L. M. WAGNER, F. S. COLLINS, D. L. OXENDER 112 Molecular Cloning of an Invertebrate Glutamate Receptor Subunit Expressed in Drosophila Muscle: C. M. SCHUSTER, A. ULTSCH, P. SCHLOSS, J. A. Cox, B. SCHMIrr, H. BETZ 115 Functional Modulation of Brain Sodium Channels by Protein Kinase C Phosphorylation: R. NUMANN, W. A. CATTERALL, T. SCHEUER 118 Establishment of the Mesoderm-Neuroectoderm Boundary in the Drosophila Embryo: D. KOSMAN, Y. T. IP, M. LEVINE, K. ARoRA
254 (5028)
Science 254 (5028), 7-137.
http://science.sciencemag.org/content/254/5028
PERMISSIONS
http://www.sciencemag.org/help/reprints-and-permissions
Use of this article is subject to the Terms of Service Science (print ISSN 0036-8075; online ISSN 1095-9203) is published by the American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. 2017 © The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. The title Science is a registered trademark of AAAS.
Downloaded from http://science.sciencemag.org/ on June 28, 2018
ARTICLE TOOLS