Dynamics and Control of Biological Systems Chapter 24
Chapter 24 addresses a variety of analysis problems in t biosystems: • Systems Biology • Gene Regulation • Circadian Rhythm Clock Network • Signal Transduction Networks • Chemotaxis • Insulin Mediated Glucose Uptake • Simple Phosphorylation Transduction Cascade
What is “Systems Biology”?
[WTEC Benchmark Study (2005): M. Cassman, A. Arkin, F. Doyle, F. Katagiri, D. Lauffenbu [also: Nature, Dec 22, 2005]
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Primary Definition: The understanding of biological netw behavior through the application of modeling and sim tightly linked to experiment Related Ideas – Identification and validation of networks – Creation of appropriate datasets – Development of tools for data acquisition and software
Motivation: Phenotype is governed by the behavior of n rather than the operation of single genes. Understan dynamics of even the simplest biological networks re application of modeling and simulation.
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Synthesis
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Synthesis of Heat Shock Proteins (FtsH and DnaK)
HEAT
Folding Process
Folde
DNAK Binding to 32
Figure 24.1 Feedback and feedforward control loop regulate heat shock in bacteria (modified from El-Sam 2006).
